CIL offers a number of reagents that are helpful for NMR investigations of biological systems. These reagents include deuterated buffers and reducing agents, ¹⁷O-enriched water, glycerol (¹²C,D₈) for low-temperature DNP, and deuterated alkanes for reverse micelles.

Choline-O-Sulfate

Dr. Kaori Wakamatsu from Gunma University has pioneered the use of choline-O-sulfate (COS) and uniformly deuterated choline-O-sulfate (COS-D₁₃) for use in protein NMR studies. His results show significant
improvement in stabilizing soluble forms of protein in solution with a concurrent increase in sensitivity in multidimensional NMR data sets acquired at near-human physiological temperatures.

 

Reverse Micelles

NMR spectroscopy of encapsulated proteins dissolved in low-viscosity fluids is emerging as a powerful supplement to traditional solution NMR approaches.

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Other Biomolecular NMR

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