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Synthetic Intermediates for Deuterated Pharmaceuticals

Stable Isotope-Labeled Synthetic Intermediates

In recent years some pharmaceutical companies have begun to investigate deuteration of molecules that may provide advantages over their existing non-deuterated counterparts. In addition, increasing research into the potential medical advantages of new deuterated drugs is also occurring. With the largest deuterated intermediate production capacity in the world we are able to supply all scales from research to commercial production. If this in an area of interest for you then please don’t hesitate to contact us to discuss you needs.

The potential advantages of deuterated pharmaceuticals:

Improved metabolic profile. The improved metabolic profile may potentially reduce or eliminate unwanted side effects or undesirable drug interactions.Synthetic Intermediates Image

Improved oral bioavailability. Deuteration in some compounds has reduced the presystemic metabolism that occurs in the digestive track allowing more of the unmetabolized drug to reach its target.

Increased half-life. Deuterated compounds can have a slower pharamacokinetic affect extending the absorption  and distribution in the body. This may decrease the number of doses that a patient may require in certain time period compared to its non-deuterated counterpart.

Catalog No. Description
DLM-112 Acetaldehyde (D4, 99%)
DLM-12 Acetic acid-d4 (D, 99.5%)
DLM-1556 Acetic acid (OD, 98%)
DLM-1162 Acetic anhydride (D6, 98%)
DLM-9 Acetone-d6 (D, 99.9%)
DLM-247 Acetyl chloride (D3, 98%)
DLM-855 Acrylic acid (+ 0.1% 4-methoxyphenol) (2,3,3-D3, 98%)  <5% H2O
DLM-862 Aniline (ring-D5, 98%)
DLM-1 Benzene-d6 (D, 99.5%)
DLM-494 Biphenyl (D10, 98%)
DLM-1315 Borane (D3, 98%) (1 molar in THF) (+0.005M NaBD4)
DLM-4747 Borane methylsulfide complex (D3, 99%)
DLM-398 Bromobenzene (D5, 99%)
DLM-874 Bromoethane (D5, 98%)
DLM-181 1,4-Butanediol (2,2,3,3-D4, 98%)
DLM-1664 tert-Butanol (D10, 98%)
DLM-1116 tert-Butyl chloride (D9, 98%)
DLM-263 Chlorobenzene-d5 (D, 99%)
DLM-337 Chlorobenzene (D3, 99%)
CNLM-7289 Cyanamide (13C, 99%; 15N2, 98%) (stabilized with <0.1% acetic acid)
DLM-1560 Cyclohexanone (D10, 98%)
DLM-2781 Cyclopentyl bromide (D9, 98%)
DLM-1003DR Deuterium (D, 99.96) <400 PPM HD
DLM-408DR Deuterium (D, 99.8%) (D2, 99.6% + HD, 0.4%)
DLM-458DR Deuterium chloride (D,99%)
DLM-3 Deuterium chloride (D, 99.5%) DCl 35% w/w solution in D2O
DLM-2 Deuterium chloride (D, 99.5%) DCl 20% w/w solution in D2O
DLM-4DR Deuterium oxide (D, 99.9%)
DLM-4-99 Deuterium oxide (D, 99%)
DLM-4DR-99.8 Deuterium oxide (D, 99.8%)
DLM-195 1,2-Dibromoethane-d4 (D, 99%)
DLM-158 1,2-Dichlorobenzene-d4 (D, 99%)
DLM-3903 Dimethyl carbonate (D6, 99%)
DLM-196 Dimethyl sulfate (D6, 98%)
DLM-10 Dimethyl sulfoxide-d6 (D, 99.9%)
DLM-25 N,N-Dimethylformamide-d7 (D,99.5%)
DLM-1670 N,N Dimethylformamide (formyl-D, 98-99%)
DLM-31 Ethanol-d6 (D, 99%) anhydrous
DLM-16 Ethanol-d (D, 99%) <6% D2O
DLM-9660 N-Ethylaniline (D10, 98%)
DLM-9626 N-Ethylaniline (ethyl-D5, 98%)
DLM-347 Ethylene (D4, 98%)
DLM-805 Formaldehyde (D2, 98%) (~20% w/w in D2O)
DLM-286 Formic acid (D2, 98%) <5% D2O
DLM-743 Formic acid (formyl-D, 98%) <5% H2O
DLM-423 n-Heptane (D16, 98%)
DLM-1023 Iodoethane (1,1-D2, 98%) + copper wire
DLM-1024 Iodoethane (2,2,2-D3, 98%) + copper wire
DLM-272 Iodoethane (D5, 99%) + copper wire
DLM-44 Isopropanol-d8 (D, 99%)
DLM-6201 a-Ketoglutaric acid (3,3,4,4-D4, 98%) CP 90%
DLM-1945 bis(2-Chloroethoxy) methane (chloroethoxy-D8, 98%)
DLM-1981 Methanesulfonic acid (D4, 97-98%)
DLM-24RG Methanol-d4 (D, 99.5%)
DLM-15 Methanol-d (D, 99%)
DLM-651 Methyl formate (formyl-D, 99%)
DLM-362 Methyl iodide + copper wire (D3, 99.5%)
DLM-9707 Methyl methanesulfonate (O-methyl-D3, 98%)
DLM-1500DR Methylamine (D3, 98%)
DLM-289 Methylamine·HCl (methyl-D3, 98%)
DLM-3484 Morpholine (2,2,3,3,5,5,6,6-D8, 98%)
DLM-295 2-Nitrophenol (ring-D4, 98%)
DLM-296 4-Nitrophenol (ring-D4, 98%)
DLM-619 Octanoic acid (D15, 98%)
DLM-300 Paraformaldehyde (D2, 99%)
DLM-370 Phenol (D6, 98%)
DLM-788 Phthalic anhydride (D4, 98%)
DLM-9813 Pivalic acid (trimethyl-D9, 98%)
DLM-9662 Pyrrolidine (2,2,3,3,4,4,5,5-D8, 98%)
DLM-226 Sodium borodeuteride (D4, 99%) CP 90-95%
DLM-45DR Sodium deuteroxide (D, 99.5%) 40% in D2O
DLM-1361 Sodium formate (D, 98%)
DLM-8206 Sodium 2,2-dimethyl-2silapentane-5-sulfonate (DDS) (D6, 98%)
DLM-33DR Sulfuric acid-d2 (D, 99%) 96-98% in D2O
DLM-36 Tetrahydrofuran-d8 (D, 99.5%)
DLM-2729 Tetramethylsilane (D12, 98%)

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